Viridisol M

This solvent is an excellent replacement for tetrahydrofuran (THF) in Grignard and other organometallic reactions. It may replace chlorinated solvent as well as Hexane in some specific reactions. MeTHF has a number of properties that make it a preferred solvent.

It has limited miscibility with water facilitates easy product recovery, can be easily dried with lower losses and lower recycle costs compared to THF, and gives cleaner phase separations compared to other solvents.

It’s especially useful for producing high concentrations of reagents.Gives high yields of benzyl and allyl Grignard, with minimal formation of dimer impurities. Gives improved yields of addition product in systems where THF gives high yields of reduction product. Permits higher reaction temperature and lower losses from reactor condensers.

MeTHF is ICH Q3C (R9) Class 3 classified for Active Pharmaceutical Ingredients production, can be used in detergency formulations (Ecocert approved), and gives high yields in lipophilic extraction for Cosmetic ingredients (COSMOS approved).

MeTHF has been found to be a very effective solvent for biphasic reactions, especially for reactions with aqueous NaOH such as alkylation, amidation and nucleophilic substitution reactions. MeTHF gives clean phase separations in these reactions and high reactivity.  MeTHF is easy to dry (forms azeotrope like toluene). MeTHF is easy to recover in high yield by azeotropic distillation and recycle.