Category : Cosmetic / Personal care - Preservatives / 1 - MinaSolve Hexam (Hexamidine) / CAS number : 659-40-5

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1 - MinaSolve Hexam (Hexamidine)




MIinaSolve Hexam (Hexamidine Diisethionate) is a hydrosoluble antimicrobial cationic substance with a wide spectrum of activity against bacteria, fungi and yeasts.
Hexamidine may be used as a polyvalent preservative, as well as a cutaneous aseptizer, more and more used by the cosmetic industry.
• INCI: Hexamidine diisethionate


• Approved: USA, EC, Australia, Canada, China (INCI listed).


Hexamidine has strong microbiostatic and/or microbicidal activity against:
  - Gram (+) bacteria: Staphylococcus, Sarcina, Streptococcus, Corynebacterium, Propionibacterium, Bacillus,
  - Gram (-) bacteria: Escherichia, Proteus, Klebsiella, Salmonella, Serratia,
  - Gram (-) bacteria, oxydase (+): Pseudomonas,
  - Fungi: Aspergillus, Penicillium, Actinomyces, Geotrichum, Trichophyton, Hormodendron,
  - Yeasts: Candida, Pityrosporum.

• The antimicrobial effects of Hexamidine varies according to:
  - the concentration and duration of contact with the anti-microbial agent,
  - the number of micro-organisms,
  - the nature and virulence of the germs,
  - the properties and characteristics of the medium.


Hexamidine is suitable for incorporation into cosmetic and hygiene preparations, such as emulsions, masks, gels, aqueous and alcoholic solutions, foaming preparations, sprays, sticks:

1. for their microbiological stabilization. We recommend a special study for each cosmetic formulation,
2. for a local aseptizing activity on skin and relative areas (hair...). For example:
    • care of oily skin and/or skin with acneic tendencies because of:
      - its antimicrobial effect on specific strains,
      - its inhibiting effect of the lipase of P. acnes,
      - its indirect anti-irritating effect (slows the hydrolysis of the sebaceous triglycerides),
    • anti-dandruff care (action on Pityrosporum ovale),
    • deodorant preparations.


, has a good cutaneous/mucous local tolerance and has an excellent coefficient of security compared to other antiseptics. It resists to inactivation by sebum, and is a substantive and an indirect anti-irritant for the skin.

Hexamidine contains neither free nor combined formaldehyde, has a good cutaneous-mucous local tolerance and has an excellent coefficient of security (safe and effective) compared to other antiseptics. It remains active in the presence of sebum and acts as an anti-irritant for the skin. Its specific antimicrobial activity is not affected by the presence of abundant cutaneous secretions, especially in the cases of oily or acne-prone skin types. 

Hexamidine has an effective antimicrobial action against acne-causing bacteria (P. acnes and Staphylococcus epidermis) and against aerobic and anaerobic bacteria and fungi often associated with acne, indirectly playing an anti-inflammatory role.

Few products are recommended for infants or children. However, Hexamidine, as an antiseptic, is safe to use on infants, children, teens and adults.


1. Dose of use:
     - as a cutaneous aseptizer: 0.10%,
     - as a preservative: 0.01% to 0.1%.

The relevant antimicrobial protection of the cosmetic product has to be checked by a challenge test.

2. Solubility: Hexamidine is soluble in water (80°C) and propylene glycol (60°C), soluble in ethanol and insoluble in oils and fats.

3. Mode of incorporation: Hexamidine must be dissolved under stirring into the formula’s water previously heated to 80°C. It can also be introduced as a mother solution in propylene glycol. This way is recommended in the case of anionic emulsions and nonionic emulsions with alkyl-glucosides and sucrose esters.


Hexamidine is a cationic substance, thus it is incompatible or interacts with all anionic raw materials. In most cases, this incompatibility leads either to a crystallization of Hexamidine, or to a more complex precipitation.
To avoid this phenomenon, particularly in the formulation of limpid, transparent products, it is imperative to "neutralizeHexamidine with anionic surfactants, before its introduction into the product.
The suitable pH is between 3 and 8, avoid high alkaline medium.


1. Aspect: white powder with a weak odor.
2. Specifications: upon request.

Recommended as a safe preservative in cosmetics at concentrations up to and including
0.1% (International Journal of Toxicology, Vol. 26, No. 3 Suppl, 79-88 (2007))


    When using Hexamidine as preservative for cosmetic products, a microbiological study should be performed to check:
    - the absence of incompatibilities,
    - the exact dosage according to the panel of micro-organisms tested and the kinetics of negativation, selected by the challenge test,
    - the possible necessity to associate other preservatives with Hexamidine.

    can be used at 0.10% in topical preparations to kill harmful micro-organisms on the skin's surface.
    Hexamidine can be used for:
    • care of oily skin with acneic tendency,
    • care of pityrosporoses of the face (= seborrheic state) and the scalp (pityriasis capitis or dandruff state).
    • deodorant preparations.

In its original packaging, at 15 - 25°C.


• DCIHexamidine diisethionate

• Molecular formula: C24 H38 NO10 S2

• Molecular weight: 606.72

• Synonyms
    Hexamidine 2-hydroxyethansulfonate; 
    4-[6-(4-Carbamimidoylphenoxy)hexoxy]benzenecarboximidamide 2-hydroxyethanesulfonnate (1:2)

• Links
Wikipedia; Hot ingredient; SCCNF's opinion


Category : Cosmetic / Personal care - Preservatives
CAS number : 659-40-5
Formula :  

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